Pyrimethamine in Prophylaxis of Malaria

Agranulocytosis during malaria prophylaxis with Maloprim (pyrimethamine and dapsone).

A case of agranulocytosis during malaria prophylaxis with Maloprim (pyrimethamine and dapsone) is described. At the recommended dose of one tablet weekly this is apparently a rare occurrence but highlights one of the hazards in a changing climate of malarial prophylaxis in which the use of Maloprim is increasing.

Quinine Prophylaxis in Malaria

In the effect of quinine on the malarial parasite we have perhaps the most remarkable example of the specific action of a drug in the whole range of medicine and one which has stood the test of two and a half centuries. Yet we have the apparent paradox of the frequently reported failure of the drug prophylactically against malaria. It is abundantly proved that when a primary infection of malari...

Prophylaxis of Malaria

Malaria prevention in travelers to endemic areas remains dependent principally on chemoprophylaxis. Although malaria chemoprophylaxis refers to all malaria species, a distinction should be drawn between falciparum malaria prophylaxis and the prophylaxis of the relapsing malaria species (vivax & ovale). While the emergence of drug resistant strains, as well as the costs and adverse reactions to ...

Stepwise acquisition of pyrimethamine resistance in the malaria parasite.

The spread of high-level pyrimethamine resistance in Africa threatens to curtail the therapeutic lifetime of antifolate antimalarials. We studied the possible evolutionary pathways in the evolution of pyrimethamine resistance using an approach in which all possible mutational intermediates were created by site-directed mutagenesis and assayed for their level of drug resistance. The coding seque...

Malaria prophylaxis for travellers.